Monitor Closely (one)crofelemer raises amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Crofelemer has the possible to inhibit CYP3A4 at concentrations predicted while in the gut; not likely to inhibit systemically simply because minimally absorbed.Impact of coadministration of the twin CYP3A4 and CYP